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PROTOPORPHYRINOGEN OXIDASE
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DeCS
Descriptor
English
:
Protoporphyrinogen Oxidase
Descriptor
Spanish
:
Protoporfirinógeno-Oxidasa
Descriptor
Portuguese
:
Protoporfirinogênio Oxidase
Tree Number:
D08.811.682.660.600
D12.776.543.697
Definition
English
:
A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of PROTOPORPHYRINOGEN IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the
HEME
and
CHLOROPHYLL
pathways in
plants
, and is the molecular target of diphenyl ether-type
herbicides
. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of
protoporphyrinogen oxidase.
Entry Combination - descr/qualif
English
:
Protoporphyrinogen Oxidase
/
deficiency
use
Porphyria, Variegate
History Note
English
:
2006(1975)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
50629
Unique Identifier:
D050768
Occurrence in VHL
:
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